Brain energy metabolism in streptozotocin-diabetes
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چکیده
منابع مشابه
Brain Regulation of Energy Metabolism
In healthy individuals, energy intake is in balance with energy expenditure, which helps to maintain a normal body weight. The brain's inability to control energy homeostasis underlies the pathology of hyperphagia and obesity. The brain detects body energy excess and deficit by sensing the levels of circulating metabolic hormones and nutrients and by receiving metabolic information from the per...
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Living cells require energy to perform work, to maintain their organized structures, to synthesize cellular components, to generate electric currents and many other processes. Energy metabolism is a highly coordinated cellular activity in which enzymes are organized into discrete metabolic pathways that cooperate in degrading energy-rich nutrients from the environment. Glucose is the principal ...
متن کاملStreptozotocin-induced diabetes progressively increases blood-brain barrier permeability in specific brain regions in rats.
This study investigated the effects of streptozotocin-induced diabetes on the functional integrity of the blood-brain barrier in the rat at 7, 28, 56, and 90 days, using vascular space markers ranging in size from 342 to 65,000 Da. We also examined the effect of insulin treatment of diabetes on the formation and progression of cerebral microvascular damage and determined whether observed functi...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1988
ISSN: 0264-6021,1470-8728
DOI: 10.1042/bj2490057